new advances in diagnosis of latent tuberculosis infection: a review article

نویسندگان

masoud mardani infectious diseases and tropical medicine research center , shahid beheshti university of medical sciences,tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences)

zahra abtahian infectious diseases and tropical medicine research center , shahid beheshti university of medical sciences,tehran, ir iran; infectious diseases and tropical medicine research center, shahid beheshti university of medical sciences, tehran, ir iran. tel: +98-2122439963-8, fax: +98-2122439964,سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences)

چکیده

conclusions here we review the clinical applications, advantages, and limitations of the tuberculin skin test and interferon-gamma release assays and provide an overview of the most recent systematic reviews conducted for the comparison of these tests. context it has been estimated that one-third of the world’s population are suffering from latent tuberculosis infection (ltbi). in order to control tuberculosis in high-risk groups proper diagnosis and treatment is essential. evidence acquisition useless and expensive tests such as unfocused population-based tests can lead to futile and unnecessary treatments. targeted screening approaches and individualization of ltbi treatment protocols must be a priority. results diagnostic methods with immune based tests such as the tuberculin skin test (tst) or interferon gamma release assays (igra) can accurately detect ltbi. however, interferon-gamma release assays have higher specificity than tst in bacille camette-gurin (bcg)-vaccinated populations; both tests are precise to identify latent tuberculosis. however, it is of great concern that both tests have insignificant roles in predicting risk of progression to active tuberculosis.

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عنوان ژورنال:
archives of pediatric infectious diseases

جلد ۳، شماره ۱ TB، صفحات ۰-۰

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